Does niacinamide cause skin irritation? Can I get a prescription without it?

Niacinamide is an ingredient that is extremely well-tolerated and is unlikely to cause skin irritation. Any skin irritation that you experience is more likely to be caused by the other active ingredients in your medication. We are unable to remove or adjust the percentage of niacinamide in the formulas, but we do have some topicals that do not have Niacinamide.